RA Cream

RA cream is indicated for the preparation of remodelling and restoring photo-damaged and intrinsically aged skin as a nightly application. For an individual who has clinical signs of photo-aged or intrinsically aged skin, we can talk about the key changes thatRA cream can bring about in both the epidermis and dermis. RA cream will ‘Clean Out” the damage to make way for the powerful re-building of Dermaheal skin speciἀc growth factors. RA cream gets the skin back in shape and ‘prepared’ to be fixed.




RA cream is a highly concentrated retinoic acid analog cream.


RA cream is a unique blend of modern emollients, sage extract, L-serine amino acids, hyaluronic acid and a patented retinoic acid analog.

How to use RA cream

RA cream is applied once daily, preferably at night. A broad spectrum sunscreen is advised for use while using RA cream. RA cream must be stopped 2 days before professional skin resurfacing, IPL or laser therapy.

What are Retinoids?

Retinoids are a group of organic chemical compounds that are related to Vitamin A (Retinol). They are lipid soluble and are essential for skin cell homeostasis. Retinoids have many important and diverse functions throughout the body including roles in vision, regulation of cell proliferation and differentiation, growth of bone tissue, immune function, and activation of tumour suppressor genes. Retinoids can be catagorised as either natural or synthetic (analog). Naturally occurring retinoids include retinyl palmitate, retinol, retinaldehyde and retinoic acid. These retinoids are usually derived from the diet and end up as retinol in the bloodstream. This retinol, when entering the skin, undergoes one of two chemical changes. It is either converted into a storage form (retinyl palmitate) found primarily in the liver and skin or it is converted into an ‘active form’ which is retinoic acid.

Synthetic retinoids (a.k.a. retinoic acid analogs) act like retinoids but are not the same molecule as RA. Natural retinoids such as tretinoin (another name for retinoic acid) activate ALL of the three RARs (and RXRs) and as a result are often associated with irritancy and other undesirable side effects.

Synthetic retinoids have been ‘fine tuned’ to still target SELECTED RARs thereby reducing many of the undesirable side effects typical of RA. Synthetic retinoids have become mainstream in prescription retinoid therapy more recently for this very reason.


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